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Neuroticism

near STAG1 · rs6795372

Where this position leads

What the study found

Who was studied 449,484 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 6.33 z score lower (95% confidence interval -); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 3, band 3q22.3 — in an intron of STAG1-DT.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Neuroticism — no copies of the reported risk allele.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Neuroticism.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Neuroticism compared to the general population.

Source

Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways

Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB, White T, Tiemeier H

and 6 more — show all

Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D

23andMe Research Team

Nature genetics · 2018 · PMID 29942085

Questions about rs6795372

What is rs6795372?

rs6795372 is a single position in the genome, in or near the near STAG1 gene. Published research associates it with neuroticism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6795372 linked to?

On MyGeneLog this position is linked to Neuroticism. The research behind each link, and its sources, are set out on that condition page.

Does having rs6795372 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6795372 come from?

GWAS Catalog, Nat Genet 2018, PMID:29942085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Neuroticism (rs6795372). MyGeneLog™. https://www.mygenelog.com/variants/rs6795372

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