0 1862217Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot6Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 960 Han Chinese ancestry cases, 1,499 Han Chinese ancestry controls; replicated in 3,316 Han Chinese ancestry cases, 4,516 Han Chinese ancestry controls.
The effect
Each copy of the A allele carried 1.44 times the odds of Adolescent idiopathic scoliosis (95% confidence interval 1.37–1.52); p = 1 × 10−36.
How common The A allele had a frequency of about 45% in the people studied.
Where it sits Chromosome 10, band 10q24.32 — in a regulatory region of LBX1-AS1.
What each result means
A/ATwo copies of the version the research linked to Adolescent idiopathic scoliosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Adolescent idiopathic scoliosis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Adolescent idiopathic scoliosis. This is the starting point the study compared everyone against.
Nature communications · 2015 · PMID 26394188 · open access
Questions about rs678741
What is rs678741?
rs678741 is a single position in the genome, in or near the LBX1AS1 gene. Published research associates it with adolescent idiopathic scoliosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs678741 linked to?
On MyGeneLog this position is linked to Adolescent Idiopathic Scoliosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs678741 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs678741 come from?
GWAS Catalog, Nature communications 2015, PMID:26394188. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1862217Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot6Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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