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Ascending aorta maximum area

LINC02269 · rs67846163

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 32,590 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 16.3 lower; p = 6 × 10⁻³¹.

How common The A allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 4, band 4q34.1 — in an intron of LINC02269.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Ascending aorta maximum area compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Ascending aorta maximum area.

G/G Published research associates this genotype with typical/baseline likelihood of Ascending aorta maximum area — no copies of the reported risk allele.

Source

Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities

Francis CM, Futschik ME, Huang J, Bai W, Sargurupremraj M, Teumer A, Breteler MMB, Petretto E, Ho ASR, Amouyel P, Engelter ST, Bülow R

and 11 more — show all

Völker U, Völzke H, Dörr M, Imtiaz MA, Aziz NA, Lohner V, Ware JS, Debette S, Elliott P, Dehghan A, Matthews PM

Nature communications · 2022 · PMID 35922433 · open access

Questions about rs67846163

What is rs67846163?

rs67846163 is a single position in the genome, in or near the LINC02269 gene. Published research associates it with ascending aorta maximum area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs67846163 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs67846163 come from?

GWAS Catalog, Nature communications 2022, PMID:35922433. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ascending aorta maximum area (rs67846163). MyGeneLog™. https://www.mygenelog.com/variants/rs67846163

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