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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 16,204 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 2.64 μm lower (95% confidence interval 1.72-3.57); p = 2 × 10−8.
How common The A allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 3, band 3q22.3 — in an intron of STAG1.
What each result means
A/ATwo copies of the version the research linked to Central corneal thickness. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Central corneal thickness. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Central corneal thickness. This is the starting point the study compared everyone against.
Communications biology · 2019 · PMID 31798171 · open access
Questions about rs6775314
What is rs6775314?
rs6775314 is a single position in the genome, in or near the STAG1 gene. Published research associates it with central corneal thickness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6775314 linked to?
On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.
Does having rs6775314 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6775314 come from?
GWAS Catalog, Communications biology 2019, PMID:31798171. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 514Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others4Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Central corneal thickness (rs6775314). MyGeneLog™. https://www.mygenelog.com/variants/rs6775314