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LDL cholesterol

RTL9 · rs67648651

Where this position leads

Conditions: Cholesterol (LDL, HDL and Total), Colon Polyp

rs67648651 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Condition: Colon Polyp Colon Polyp Condition rs67648651 rs67648651 RTL9

What the study found

Who was studied 343,621 European ancestry individuals, 72,866 East Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0202 lower (95% confidence interval 0.016-0.024); p = 3 × 10−25.

Where it sits Chromosome X, band Xq23 — in an intron of RTL9.

What each result means

C/C Two copies of the version the research linked to LDL cholesterol. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to LDL cholesterol. That is a smaller link than two copies.
T/T No copy of the version the research linked to LDL cholesterol. This is the starting point the study compared everyone against.
Source

Questions about rs67648651

What is rs67648651?

rs67648651 is a single position in the genome, in or near the RTL9 gene. Published research associates it with ldl cholesterol. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs67648651 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total), Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs67648651 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs67648651 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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LDL cholesterol (rs67648651). MyGeneLog™. https://www.mygenelog.com/variants/rs67648651

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