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Who was studied 7,554 European ancestry cases, 1,367,006 European ancestry controls.
The effect
Each copy of the T allele carried 1.14 times the odds of Sarcoidosis (95% confidence interval 1.09-1.19); p = 5 × 10−10.
How common The T allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 2, band 2p16.1 — between genes, 1.5 kb from PAPOLG.
What each result means
C/CNo copy of the version the research linked to Sarcoidosis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Sarcoidosis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Sarcoidosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40075078 · open access
Questions about rs6761132
What is rs6761132?
rs6761132 is a single position in the genome, in or near the near PAPOLG gene. Published research associates it with sarcoidosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6761132 linked to?
On MyGeneLog this position is linked to Sarcoidosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs6761132 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6761132 come from?
GWAS Catalog, Nature communications 2025, PMID:40075078. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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