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Gout (PheCode 274.1)

near TMEM18 · rs6760274

Where this position leads

Condition: Gout

rs6760274 Condition: Gout Gout Condition rs6760274 rs6760274 near TMEM18

What the study found

Who was studied 14,437 African American or Afro-Caribbean cases, 103,731 African American or Afro-Caribbean controls, 3,643 Hispanic or Latin American cases, 55,120 Hispanic or Latin American controls, 1,243 East Asian ancestry cases, 5,416 East Asian ancestry controls, 42,034 European ancestry cases, 397,989 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0771 higher (95% confidence interval 0.057-0.098); p = 3 × 10−15.

How common The G allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 2, band 2p25.3 — between genes, 11.6 kb from TMEM18.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Gout (PheCode 274.1) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gout (PheCode 274.1).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gout (PheCode 274.1) compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs6760274

What is rs6760274?

rs6760274 is a single position in the genome, in or near the near TMEM18 gene. Published research associates it with gout (phecode 274.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6760274 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs6760274 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6760274 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gout (PheCode 274.1) (rs6760274). MyGeneLog™. https://www.mygenelog.com/variants/rs6760274

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