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Hexanoylcarnitine levels

ETFDH · rs67481496

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0916 higher (95% confidence interval 0.069-0.114); p = 6 × 10−16.

How common The A allele had a frequency of about 73% in the people studied.

Where it sits Chromosome 4, band 4q32.1 — in an intron of ETFDH.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hexanoylcarnitine levels compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hexanoylcarnitine levels.
T/T Published research associates this genotype with typical/baseline likelihood of Hexanoylcarnitine levels — no copies of the reported risk allele.
Source
Rare and common genetic determinants of metabolic individuality and their effects on human health
Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J
and 24 more — show all
Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C
Nature medicine · 2022 · PMID 36357675 · open access

Questions about rs67481496

What is rs67481496?

rs67481496 is a single position in the genome, in or near the ETFDH gene. Published research associates it with hexanoylcarnitine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs67481496 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs67481496 come from?

GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hexanoylcarnitine levels (rs67481496). MyGeneLog™. https://www.mygenelog.com/variants/rs67481496

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