Who was studied 1,726 European ancestry cases, 5,482 European ancestry controls; replicated in 1,912 European ancestry cases, 5,938 European ancestry controls, 781 African American cases, 876 African American controls.
The effect
Each copy of the C allele carried 1.18 times the odds of Sarcoidosis (95% confidence interval 1.11-1.25); p = 2 × 10−8.
How common The C allele had a frequency of about 31% in the people studied.
Where it sits Chromosome 2, band 2q33.2 — in an intron of FAM117B.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Sarcoidosis compared to the general population.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Sarcoidosis.
T/TPublished research associates this genotype with typical/baseline likelihood of Sarcoidosis — no copies of the reported risk allele.
American journal of respiratory and critical care medicine · 2015 · PMID 26051272
Questions about rs6748088
What is rs6748088?
rs6748088 is a single position in the genome, in or near the FAM117B gene. Published research associates it with sarcoidosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6748088 linked to?
On MyGeneLog this position is linked to Sarcoidosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs6748088 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6748088 come from?
GWAS Catalog, Am J Respir Crit Care Med 2015, PMID:26051272. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.