Sensitive

Systemic lupus erythematosus

NAB1 · rs6733720

Where this position leads

Condition: Systemic Lupus Erythematosus

rs6733720 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs6733720 rs6733720 NAB1

What the study found

Who was studied 16,491 European ancestry cases, 1,202,106 European ancestry controls, 5,051 East Asian ancestry cases, 185,362 East Asian ancestry controls, 740 African American or Afro-Caribbean cases, 120,993 African American or Afro-Caribbean controls, 212 Hispanic or Latin American cases, 59,641 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.122 lower (95% confidence interval 0.079-0.165); p = 3 × 10−15.

Where it sits Chromosome 2, band 2q32.2 — in an intron of NAB1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic lupus erythematosus compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic lupus erythematosus.
G/G Published research associates this genotype with typical/baseline likelihood of Systemic lupus erythematosus — no copies of the reported risk allele.
Source

Questions about rs6733720

What is rs6733720?

rs6733720 is a single position in the genome, in or near the NAB1 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6733720 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs6733720 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6733720 come from?

GWAS Catalog, Mammalian genome : official journal of the International Mammalian Genome Society 2026, PMID:42581184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs6733720). MyGeneLog™. https://www.mygenelog.com/variants/rs6733720

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