Sensitive

Sudden cardiac arrest in coronary artery disease

RAB3GAP1 · rs6730157

Where this position leads

Condition: Coronary Artery Disease

rs6730157 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs6730157 rs6730157 RAB3GAP1

What the study found

Who was studied 948 European ancestry cases, 3,050 European ancestry controls.

The effect Each copy of the G allele carried 1.60 times the odds of Sudden cardiac arrest in coronary artery disease (95% confidence interval 1.48-1.72); p = 5 × 10−12.

How common The G allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 2, band 2q21.3 — in an intron of RAB3GAP1.

What each result means

A/A No copy of the version the research linked to Sudden cardiac arrest in coronary artery disease. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Sudden cardiac arrest in coronary artery disease. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Sudden cardiac arrest in coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs6730157

What is rs6730157?

rs6730157 is a single position in the genome, in or near the RAB3GAP1 gene. Published research associates it with sudden cardiac arrest in coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6730157 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs6730157 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6730157 come from?

GWAS Catalog, PloS one 2013, PMID:23593153. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sudden cardiac arrest in coronary artery disease (rs6730157). MyGeneLog™. https://www.mygenelog.com/variants/rs6730157

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