ALS2CR12 · rs6714430
Where this position leads
Condition: Basal Cell Carcinoma
What the study found
Who was studied 31,787 European ancestry cases, 619,351 European ancestry controls.
The effect Each copy of the C allele carried 1.15 times the odds of Basal cell carcinoma (95% confidence interval 1.12-1.18); p = 5 × 10−55.
How common The C allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 2, band 2q33.1 — in an intron of CASP8.
rs6714430 is a single position in the genome, in or near the ALS2CR12 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2019, PMID:31174203. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Basal cell carcinoma (rs6714430). MyGeneLog™. https://www.mygenelog.com/variants/rs6714430