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NMNAT1 protein levels

ECRG4 · rs66989638

Where this position leads

Condition: Osteoarthritis

rs66989638 Condition: Osteoarthritis Osteoarthritis Condition rs66989638 rs66989638 ECRG4

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0629 lower (95% confidence interval 0.045-0.081); p = 6 × 10−13.

How common The A allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 2, band 2q12.2 — in an intron of ECRG4.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of NMNAT1 protein levels compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with NMNAT1 protein levels.
G/G Published research associates this genotype with typical/baseline likelihood of NMNAT1 protein levels — no copies of the reported risk allele.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs66989638

What is rs66989638?

rs66989638 is a single position in the genome, in or near the ECRG4 gene. Published research associates it with nmnat1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs66989638 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs66989638 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs66989638 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

NMNAT1 protein levels (rs66989638). MyGeneLog™. https://www.mygenelog.com/variants/rs66989638

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