Sensitive

Depression (broad)

near H2BC11 · rs66975207

Where this position leads

Condition: Depression (Self-Reported Symptoms)

rs66975207 Condition: Depression (Self-Reported Symptoms) Depression (Self-Reported Symptoms) Condition rs66975207 rs66975207 near H2BC11

What the study found

Who was studied 113,769 British ancestry cases, 208,811 British ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0111 lower (95% confidence interval 0.0074-0.0148); p = 7 × 10−9.

How common The C allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 6, band 6p22.2 — in an intron of LARRPM.

What each result means

A/A No copy of the version the research linked to Depression (broad). This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Depression (broad). That is a smaller link than two copies.
C/C Two copies of the version the research linked to Depression (broad). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs66975207

What is rs66975207?

rs66975207 is a single position in the genome, in or near the near H2BC11 gene. Published research associates it with depression (broad). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs66975207 linked to?

On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.

Does having rs66975207 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs66975207 come from?

GWAS Catalog, Nat Commun 2018, PMID:29662059. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Depression (broad) (rs66975207). MyGeneLog™. https://www.mygenelog.com/variants/rs66975207

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