Standard

Lung function (FVC)

near HLX · rs6696174

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 100,285 Chinese ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.029 L lower (95% confidence interval 0.017-0.041); p = 2 × 10⁻¹⁰.

How common The A allele had a frequency of about 45% in the people studied.

Where it sits Chromosome 1, band 1q41 — between genes, 146.1 kb from HLX.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung function (FVC) compared to the general population.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung function (FVC).

T/T Published research associates this genotype with typical/baseline likelihood of Lung function (FVC) — no copies of the reported risk allele.

Source

A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity

Zhu Z, Li J, Si J, Ma B, Shi H, Lv J, Cao W, Guo Y, Millwood IY, Walters RG, Lin K, Yang L

and 12 more — show all

Chen Y, Du H, Yu B, Hasegawa K, Camargo CA Jr, Moffatt MF, Cookson WOC, Chen J, Chen Z, Li L, Yu C, Liang L

The European respiratory journal · 2021 · PMID 33766948

Questions about rs6696174

What is rs6696174?

rs6696174 is a single position in the genome, in or near the near HLX gene. Published research associates it with lung function (fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6696174 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6696174 come from?

GWAS Catalog, The European respiratory journal 2021, PMID:33766948. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung function (FVC) (rs6696174). MyGeneLog™. https://www.mygenelog.com/variants/rs6696174

← See all variants