Who was studied 14,825 European ancestry cases, 44,000 European and unknown ancestry cases, 2,680 cases, 380,970 European ancestry controls, 123,504 European and unknown ancestry controls, 73,242 controls.
The effect
Each copy of the C allele carried 1.05 times the odds of Myocardial infarction (95% confidence interval 1.03-1.06); p = 4 × 10−10.
How common The C allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 1, band 1q21.3 — in an intron of IL6R.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Myocardial infarction — no copies of the reported risk allele.
A/CPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Myocardial infarction.
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Myocardial infarction compared to the general population.
rs6694258 is a single position in the genome, in or near the IL6R gene. Published research associates it with myocardial infarction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6694258 linked to?
On MyGeneLog this position is linked to Myocardial Infarction. The research behind each link, and its sources, are set out on that condition page.
Does having rs6694258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6694258 come from?
GWAS Catalog, European heart journal 2021, PMID:33532862. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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