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Allergic conjunctivitis

TNFSF4 · rs6691738

What the study found

Who was studied 45,734 European ancestry cases, 1,084,159 European ancestry controls.

The effect Each copy of the G allele carried 1.05 times the odds of Allergic conjunctivitis (95% confidence interval 1.03-1.06); p = 2 × 10−10.

How common The G allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 1, band 1q25.1 — in an intron of TNFSF4.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Allergic conjunctivitis compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Allergic conjunctivitis.
T/T Published research associates this genotype with typical/baseline likelihood of Allergic conjunctivitis — no copies of the reported risk allele.
Source

Questions about rs6691738

What is rs6691738?

rs6691738 is a single position in the genome, in or near the TNFSF4 gene. Published research associates it with allergic conjunctivitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6691738 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6691738 come from?

GWAS Catalog, The Journal of allergy and clinical immunology 2026, PMID:41482248. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Allergic conjunctivitis (rs6691738). MyGeneLog™. https://www.mygenelog.com/variants/rs6691738

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