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Primary biliary cirrhosis

IL12A · rs668998

Where this position leads

Condition: Primary Biliary Cholangitis

rs668998 Condition: Primary Biliary Cholangitis Primary Biliary Cholangitis Condition rs668998 rs668998 IL12A

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Primary biliary cirrhosis — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cirrhosis.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cirrhosis compared to the general population.
Source
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L, Cordell HJ, Ducker SJ, Day DB, Heneghan MA, Neuberger JM, Donaldson PT, Bathgate AJ
and 7 more — show all
Burroughs A, Davies MH, Jones DE, Alexander GJ, Barrett JC, Sandford RN, Anderson CA
UK Primary Biliary Cirrhosis (PBC) Consortium · Wellcome Trust Case Control Consortium 3
Nature genetics · 2012 · PMID 22961000 · open access

Questions about rs668998

What is rs668998?

rs668998 is a single position in the genome, in or near the IL12A gene. Published research associates it with primary biliary cirrhosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs668998 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs668998 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs668998 come from?

GWAS Catalog, Nat Genet 2012, PMID:22961000. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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