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COVID-19 (hospitalized covid vs population)

ZBTB7A · rs66833742

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 763 African ancestry cases, 24,850 African ancestry controls, 218 admixed American ancestry cases, 94,318 admixed American ancestry controls, 414 East Asian ancestry cases, 816 East Asian ancestry controls, 16,627 European ancestry cases, 749,207 European ancestry controls, 3,533 European, African or admixed American ancestry cases, 1,700 European, African or admixed American ancestry controls, 1,171 South Asian ancestry cases, 5,489 South Asian ancestry controls, 93 other admixed ancestry cases, 645 other admixed ancestry controls, 22,637 cases, 2,052,436 controls.

The effect Each copy of the T allele carried 0.93 times the odds of COVID-19 (hospitalized covid vs population) (95% confidence interval 0.91-0.95); p = 2 × 10−10.

Where it sits Chromosome 19, band 19p13.3 — in the 5′ untranslated region of ZBTB7A.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of COVID-19 (hospitalized covid vs population) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with COVID-19 (hospitalized covid vs population).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of COVID-19 (hospitalized covid vs population) compared to the general population.
Source
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A
and 43 more — show all
Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P, Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK
GenOMICC Investigators · SCOURGE Consortium · ISARICC Investigators · 23andMe COVID-19 Team
Nature · 2023 · PMID 37198478 · open access

Questions about rs66833742

What is rs66833742?

rs66833742 is a single position in the genome, in or near the ZBTB7A gene. Published research associates it with covid-19 (hospitalized covid vs population). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs66833742 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs66833742 come from?

GWAS Catalog, Nature 2023, PMID:37198478. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (hospitalized covid vs population) (rs66833742). MyGeneLog™. https://www.mygenelog.com/variants/rs66833742

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