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Who was studied 1,286 Chinese ancestry cases, 1,523 Chinese ancestry controls; replicated in up to 1,595 Chinese ancestry cases, up to 2,474 Chinese ancestry controls, up to 21,982 European ancestry cases, up to 41,944 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.234 lower (95% confidence interval 0.16-0.31); p = 9 × 10−10.
How common The T allele had a frequency of about 46% in the people studied.
Where it sits Chromosome 1, band 1p36.22 — between genes, 0.1 kb from KIAA2013.
What each result means
C/CNo copy of the version the research linked to Alzheimer's disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Alzheimer's disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Alzheimer's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024 · PMID 39023044 · open access
Questions about rs6682554
What is rs6682554?
rs6682554 is a single position in the genome, in or near the near KIAA2013 gene. Published research associates it with alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6682554 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease Risk (APOE). The research behind each link, and its sources, are set out on that condition page.
Does having rs6682554 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6682554 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2024, PMID:39023044. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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