Sensitive

Breast cancer (estrogen-receptor negative)

LGR6 · rs6678914

Where this position leads

Condition: Breast Cancer

rs6678914 Condition: Breast Cancer Breast Cancer Condition rs6678914 rs6678914 LGR6

What the study found

Who was studied 14,135 European ancestry cases, 58,126 European ancestry controls; replicated in 7,333 European ancestry cases, 42,468 European ancestry controls.

The effect Each copy of the G allele carried 1.09 times the odds of Breast cancer (estrogen-receptor negative) (95% confidence interval 1.06-1.11); p = 3 × 10−12.

How common The G allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 1, band 1q32.1 — in an intron of LGR6.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Breast cancer (estrogen-receptor negative) — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Breast cancer (estrogen-receptor negative).
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Breast cancer (estrogen-receptor negative) compared to the general population.
Source

Questions about rs6678914

What is rs6678914?

rs6678914 is a single position in the genome, in or near the LGR6 gene. Published research associates it with breast cancer (estrogen-receptor negative). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6678914 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs6678914 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6678914 come from?

GWAS Catalog, Nat Genet 2017, PMID:29058716. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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