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Monocyte percentage of white cells

NOS1AP · rs6677530

Where this position leads

Condition: Blood Cell Counts

Drug: QT-prolonging medicines

rs6677530 Condition: Blood Cell Counts Blood Cell Counts Condition Drug: QT-prolonging medicines QT-prolonging medicines Drug rs6677530 rs6677530 NOS1AP

What the study found

Who was studied 170,494 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0332 lower (95% confidence interval 0.024-0.043); p = 9 × 10−12.

How common The G allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 1, band 1q23.3 — in an intron of NOS1AP.

What each result means

A/A No copy of the version the research linked to Monocyte percentage of white cells. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Monocyte percentage of white cells. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Monocyte percentage of white cells. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, Mead D, Bouman H, Riveros-Mckay F, Kostadima MA, Lambourne JJ, Sivapalaratnam S
and 62 more — show all
Downes K, Kundu K, Bomba L, Berentsen K, Bradley JR, Daugherty LC, Delaneau O, Freson K, Garner SF, Grassi L, Guerrero J, Haimel M, Janssen-Megens EM, Kaan A, Kamat M, Kim B, Mandoli A, Marchini J, Martens JHA, Meacham S, Megy K, O'Connell J, Petersen R, Sharifi N, Sheard SM, Staley JR, Tuna S, van der Ent M, Walter K, Wang SY, Wheeler E, Wilder SP, Iotchkova V, Moore C, Sambrook J, Stunnenberg HG, Di Angelantonio E, Kaptoge S, Kuijpers TW, Carrillo-de-Santa-Pau E, Juan D, Rico D, Valencia A, Chen L, Ge B, Vasquez L, Kwan T, Garrido-Martín D, Watt S, Yang Y, Guigo R, Beck S, Paul DS, Pastinen T, Bujold D, Bourque G, Frontini M, Danesh J, Roberts DJ, Ouwehand WH, Butterworth AS, Soranzo N
Cell · 2016 · PMID 27863252 · open access

Questions about rs6677530

What is rs6677530?

rs6677530 is a single position in the genome, in or near the NOS1AP gene. Published research associates it with monocyte percentage of white cells. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6677530 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does rs6677530 affect how medicines work?

NOS1AP carries pharmacogenomic findings for QT-prolonging medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs6677530 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6677530 come from?

GWAS Catalog, Cell 2016, PMID:27863252. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Monocyte percentage of white cells (rs6677530). MyGeneLog™. https://www.mygenelog.com/variants/rs6677530

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