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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−9, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 757,601 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.183 higher (95% confidence interval 0.12-0.24); p = 1 × 10−9.
How common The G allele had a frequency of about 86% in the people studied.
Where it sits Chromosome 2, band 2p24.1 — between genes, 56.3 kb from TDRD15.
What each result means
A/ANo copy of the version the research linked to Pulse pressure. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Pulse pressure. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Pulse pressure. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs66774912 is a single position in the genome, in or near the APOB gene. Published research associates it with pulse pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs66774912 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs66774912 come from?
GWAS Catalog, Nature genetics 2018, PMID:30224653. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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