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Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 371,184 European ancestry cases, 978,703 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.0246 lower (95% confidence interval 0.016-0.033); p = 5 × 10−9.
How common The A allele had a frequency of about 85% in the people studied.
Where it sits Chromosome 9, band 9q33.3 — in an intron of DENND1A.
What each result means
A/ATwo copies of the version the research linked to Depression. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Depression. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Depression. This is the starting point the study compared everyone against.
rs667138 is a single position in the genome, in or near the DENND1A gene. Published research associates it with depression. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs667138 linked to?
On MyGeneLog this position is linked to Endometriosis and Depression: Shared Genetics. The research behind each link, and its sources, are set out on that condition page.
Does having rs667138 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs667138 come from?
GWAS Catalog, Nature medicine 2023, PMID:37464041. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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