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Who was studied 23,963 European ancestry cases, 306,942 European ancestry controls, 6,935 East Asian ancestry cases, 39,588 East Asian ancestry controls, 3,281 Sub-Saharan African ancestry cases, 2,791 Sub-Saharan African ancestry controls; replicated in 43,254 European ancestry cases, 1,471,118 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.125 lower; p = 2 × 10−17.
Where it sits Chromosome 1, band 1q41 — in an intron of LYPLAL1-DT.
What each result means
A/ATwo copies of the version the research linked to Glaucoma (primary open-angle). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Glaucoma (primary open-angle). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Glaucoma (primary open-angle). This is the starting point the study compared everyone against.
Nature communications · 2021 · PMID 33627673 · open access
Questions about rs6667536
What is rs6667536?
rs6667536 is a single position in the genome, in or near the LYPLAL1-DT gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6667536 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs6667536 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6667536 come from?
GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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