Parkinson's disease or first degree relation to individual with Parkinson's disease
DNAH17 · rs666463
0 23722327Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total23Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 15,056 European ancestry cases, 18,618 European ancestry proxy cases, 449,056 European ancestry controls; replicated in 22,632 European ancestry cases, 968,735 European ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.076 higher (95% confidence interval 0.051-0.101); p = 3 × 10−9.
How common The A allele had a frequency of about 83% in the people studied.
Where it sits Chromosome 17, band 17q25.3 — in an intron of DNAH17.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-05-11.
ClinVar record 1223031NM_173628.4(DNAH17):c.12226-99T>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Parkinson's disease or first degree relation to individual with Parkinson's disease. This is the starting point the study compared everyone against.
rs666463 is a single position in the genome, in or near the DNAH17 gene. Published research associates it with parkinson's disease or first degree relation to individual with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs666463 linked to?
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs666463 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs666463 come from?
GWAS Catalog, Lancet Neurol 2019, PMID:31701892. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 23722327Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total23Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Parkinson's disease or first degree relation to individual with Parkinson's disease (rs666463). MyGeneLog™. https://www.mygenelog.com/variants/rs666463