Sensitive

Breast cancer subtype (HER2-enriched-like vs luminal A-like)

LGR6 · rs6663303

Where this position leads

Condition: Breast Cancer

rs6663303 Condition: Breast Cancer Breast Cancer Condition rs6663303 rs6663303 LGR6

What the study found

Who was studied 5,859 European ancestry HER-enriched-like cases, 60,715 European ancestry luminal A-like cases.

The effect Each copy of the C allele shifted the measure 0.03 higher (95% confidence interval 0.016-0.044); p = 1 × 10−8.

Where it sits Chromosome 1, band 1q32.1 — in an intron of LGR6.

What each result means

C/C Two copies of the version the research linked to Breast cancer subtype (HER2-enriched-like vs luminal A-like). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Breast cancer subtype (HER2-enriched-like vs luminal A-like). That is a smaller link than two copies.
T/T No copy of the version the research linked to Breast cancer subtype (HER2-enriched-like vs luminal A-like). This is the starting point the study compared everyone against.
Source

Questions about rs6663303

What is rs6663303?

rs6663303 is a single position in the genome, in or near the LGR6 gene. Published research associates it with breast cancer subtype (her2-enriched-like vs luminal a-like). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6663303 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs6663303 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6663303 come from?

GWAS Catalog, Cancer research 2024, PMID:38832928. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Breast cancer subtype (HER2-enriched-like vs luminal A-like) (rs6663303). MyGeneLog™. https://www.mygenelog.com/variants/rs6663303

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