Sensitive

Systemic lupus erythematosus (MTAG)

near GFI1 · rs6662618

Where this position leads

Condition: Systemic Lupus Erythematosus

rs6662618 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs6662618 rs6662618 near GFI1

What the study found

Who was studied at least 5,877 East Asian ancestry cases, at least 188,588 East Asian ancestry controls, at least 14,355 European ancestry cases, at least 505,956 European ancestry controls, at least 1,393 admixed American ancestry cases, at least 2,327 admixed American ancestry controls (MTAG boosted by autoimmune diseases samples).

The effect Each copy of the T allele shifted the measure 0.083 higher (95% confidence interval 0.059-0.107); p = 1 × 10−11.

Where it sits Chromosome 1, band 1p22.1 — between genes, 2.5 kb from GFI1.

What each result means

G/G No copy of the version the research linked to Systemic lupus erythematosus (MTAG). This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Systemic lupus erythematosus (MTAG). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Systemic lupus erythematosus (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs6662618

What is rs6662618?

rs6662618 is a single position in the genome, in or near the near GFI1 gene. Published research associates it with systemic lupus erythematosus (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6662618 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs6662618 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6662618 come from?

GWAS Catalog, Nature communications 2023, PMID:36750564. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (MTAG) (rs6662618). MyGeneLog™. https://www.mygenelog.com/variants/rs6662618

← See all variants