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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 20,165 European ancestry cases, 595,231 European ancestry controls.
The effect
Each copy of the T allele carried 1.08 times the odds of acne vulgaris (95% confidence interval 1.06–1.11); p = 6 × 10−12.
How common The T allele had a frequency of about 53% in the people studied.
Where it sits Chromosome 1, band 1q32.1 — in an intron of PPP1R12B.
What each result means
G/GNo copy of the version the research linked to acne vulgaris. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to acne vulgaris. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to acne vulgaris. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 35132056 · open access
Questions about rs6658708
What is rs6658708?
rs6658708 is a single position in the genome, in or near the PPP1R12B gene. Published research associates it with acne vulgaris. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6658708 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6658708 come from?
GWAS Catalog, Nature communications 2022, PMID:35132056. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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