Standard

Age-related macular degeneration

MIR29B2CHG · rs66532523

Where this position leads

Condition: Age-Related Macular Degeneration

rs66532523 Condition: Age-Related Macular Degeneration Age-Related Macular Degeneration Condition rs66532523 rs66532523 MIR29B2CHG

What the study found

Who was studied 57,290 European ancestry cases, 324,430 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.075 lower (95% confidence interval 0.057-0.093); p = 1 × 10−16.

How common The C allele had a frequency of about 21% in the people studied.

Where it sits Chromosome 1, band 1q32.2 — in an intron of MIR29B2CHG.

What each result means

A/A No copy of the version the research linked to Age-related macular degeneration. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Age-related macular degeneration. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Age-related macular degeneration. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs66532523

What is rs66532523?

rs66532523 is a single position in the genome, in or near the MIR29B2CHG gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs66532523 linked to?

On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.

Does having rs66532523 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs66532523 come from?

GWAS Catalog, Nature genetics 2024, PMID:39623103. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Age-related macular degeneration (rs66532523). MyGeneLog™. https://www.mygenelog.com/variants/rs66532523

← See all variants