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Who was studied 48,843 European ancestry cases, 1,190,837 European ancestry controls.
The effect
The reported allele is T; the catalogue records no effect size
; p = 9 × 10−20.
How common The T allele had a frequency of about 11% in the people studied.
Where it sits Chromosome 4, band 4p15.33 — between genes, 114.7 kb from HSP90AB2P.
What each result means
C/CNo copy of the version the research linked to Carpal tunnel syndrome. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Carpal tunnel syndrome. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Carpal tunnel syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 35332129 · open access
Questions about rs66525731
What is rs66525731?
rs66525731 is a single position in the genome, in or near the near HSP90AB2P gene. Published research associates it with carpal tunnel syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs66525731 linked to?
On MyGeneLog this position is linked to Carpal Tunnel Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs66525731 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs66525731 come from?
GWAS Catalog, Nature communications 2022, PMID:35332129. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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