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Left-handedness

TUBB4A · rs66479618

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 1,766,671 European ancestry individuals.

The effect Each copy of the T allele carried 0.97 times the odds of Left-handedness; p = 6 × 10⁻¹².

How common The T allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 19, band 19p13.3 — in an intron of TUBB4A.

What each result means

C/C No copy of the version the research linked to Left-handedness. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Left-handedness. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Left-handedness. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study identifies 48 common genetic variants associated with handedness

Cuellar-Partida G, Tung JY, Eriksson N, Albrecht E, Aliev F, Andreassen OA, Barroso I, Beckmann JS, Boks MP, Boomsma DI, Boyd HA, Breteler MMB

and 106 more — show all

Campbell H, Chasman DI, Cherkas LF, Davies G, de Geus EJC, Deary IJ, Deloukas P, Dick DM, Duffy DL, Eriksson JG, Esko T, Feenstra B, Geller F, Gieger C, Giegling I, Gordon SD, Han J, Hansen TF, Hartmann AM, Hayward C, Heikkilä K, Hicks AA, Hirschhorn JN, Hottenga JJ, Huffman JE, Hwang LD, Ikram MA, Kaprio J, Kemp JP, Khaw KT, Klopp N, Konte B, Kutalik Z, Lahti J, Li X, Loos RJF, Luciano M, Magnusson SH, Mangino M, Marques-Vidal P, Martin NG, McArdle WL, McCarthy MI, Medina-Gomez C, Melbye M, Melville SA, Metspalu A, Milani L, Mooser V, Nelis M, Nyholt DR, O'Connell KS, Ophoff RA, Palmer C, Palotie A, Palviainen T, Pare G, Paternoster L, Peltonen L, Penninx BWJH, Polasek O, Pramstaller PP, Prokopenko I, Raikkonen K, Ripatti S, Rivadeneira F, Rudan I, Rujescu D, Smit JH, Smith GD, Smoller JW, Soranzo N, Spector TD, Pourcain BS, Starr JM, Stefánsson H, Steinberg S, Teder-Laving M, Thorleifsson G, Stefánsson K, Timpson NJ, Uitterlinden AG, van Duijn CM, van Rooij FJA, Vink JM, Vollenweider P, Vuoksimaa E, Waeber G, Wareham NJ, Warrington N, Waterworth D, Werge T, Wichmann HE, Widen E, Willemsen G, Wright AF, Wright MJ, Xu M, Zhao JH, Kraft P, Hinds DA, Lindgren CM, Mägi R, Neale BM, Evans DM, Medland SE

Nature human behaviour · 2021 · PMID 32989287

Questions about rs66479618

What is rs66479618?

rs66479618 is a single position in the genome, in or near the TUBB4A gene. Published research associates it with left-handedness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs66479618 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs66479618 come from?

GWAS Catalog, Nature human behaviour 2021, PMID:32989287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Left-handedness (rs66479618). MyGeneLog™. https://www.mygenelog.com/variants/rs66479618

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