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Psoriasis and related disorder (PheCode 696)

near POLI · rs664157

Where this position leads

Condition: Psoriasis

rs664157 Condition: Psoriasis Psoriasis Condition rs664157 rs664157 near POLI

What the study found

Who was studied 1,955 African American or Afro-Caribbean cases, 118,482 African American or Afro-Caribbean controls, 1,916 Hispanic or Latin American cases, 57,083 Hispanic or Latin American controls, 255 East Asian ancestry cases, 6,480 East Asian ancestry controls, 16,702 European ancestry cases, 427,092 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0929 lower (95% confidence interval 0.072-0.114); p = 1 × 10−14.

How common The T allele had a frequency of about 74% in the people studied.

Where it sits Chromosome 18, band 18q21.2 — between genes, 3.2 kb from POLI.

What each result means

C/C No copy of the version the research linked to Psoriasis and related disorder (PheCode 696). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Psoriasis and related disorder (PheCode 696). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Psoriasis and related disorder (PheCode 696). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs664157

What is rs664157?

rs664157 is a single position in the genome, in or near the near POLI gene. Published research associates it with psoriasis and related disorder (phecode 696). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs664157 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs664157 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs664157 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis and related disorder (PheCode 696) (rs664157). MyGeneLog™. https://www.mygenelog.com/variants/rs664157

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