Sensitive

Venous thromboembolism

near FAM47B · rs6632109

Where this position leads

What the study found

Who was studied 71,771 European ancestry cases, 7,482 African ancestry cases, 189 South Asian ancestry cases, 507 East Asian ancestry cases, 1,720 Hispanic cases, 1,426,717 controls.

The effect Each copy of the T allele shifted the measure 0.0345 higher (95% confidence interval 0.022-0.047); p = 3 × 10⁻⁸.

How common The T allele had a frequency of about 34% in the people studied.

Where it sits Chromosome X, band Xp21.1 — between genes, 66.3 kb from FAM47B.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Venous thromboembolism — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Venous thromboembolism.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Venous thromboembolism compared to the general population.

Source

Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors

Thibord F, Klarin D, Brody JA, Chen MH, Levin MG, Chasman DI, Goode EL, Hveem K, Teder-Laving M, Martinez-Perez A, Aïssi D, Daian-Bacq D

and 76 more — show all

Ito K, Natarajan P, Lutsey PL, Nadkarni GN, de Vries PS, Cuellar-Partida G, Wolford BN, Pattee JW, Kooperberg C, Braekkan SK, Li-Gao R, Saut N, Sept C, Germain M, Judy RL, Wiggins KL, Ko D, O'Donnell CJ, Taylor KD, Giulianini F, De Andrade M, Nøst TH, Boland A, Empana JP, Koyama S, Gilliland T, Do R, Huffman JE, Wang X, Wang X, Zhou W, Manuel Soria J, Carlos Souto J, Pankratz N, Haessler J, Hindberg K, Rosendaal FR, Turman C, Olaso R, Kember RL, Bartz TM, Lynch JA, Heckbert SR, Armasu SM, Brumpton B, Smadja DM, Jouven X, Komuro I, Clapham KR, Loos RJF, Willer CJ, Sabater-Lleal M, Pankow JS, Reiner AP, Morelli VM, Ridker PM, Vlieg AVH, Deleuze JF, Kraft P, Rader DJ, Min Lee K, Psaty BM, Heidi Skogholt A, Emmerich J, Suchon P, Rich SS, Vy HMT, Tang W, Jackson RD, Hansen JB, Morange PE, Kabrhel C, Trégouët DA, Damrauer SM, Johnson AD, Smith NL

Global Biobank Meta-Analysis Initiative; Estonian Biobank Research Team; 23andMe Research Team; Biobank Japan; CHARGE Hemostasis Working Group

Circulation · 2022 · PMID 36154123

Questions about rs6632109

What is rs6632109?

rs6632109 is a single position in the genome, in or near the near FAM47B gene. Published research associates it with venous thromboembolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6632109 linked to?

On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.

Does having rs6632109 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6632109 come from?

GWAS Catalog, Circulation 2022, PMID:36154123. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Venous thromboembolism (rs6632109). MyGeneLog™. https://www.mygenelog.com/variants/rs6632109

← See all variants