Standard
Lung function (forced vital capacity)
TULP4 · rs661857
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 475,645 European ancestry individuals, 8,590 African ancestry individuals, 85,279 East Asian ancestry individuals, 4,270 South Asian ancestry individuals, 14,668 Hispanic or Latin American individuals.
The effect
Each copy of the T allele shifted the measure 6.29 z score lower; p = 3 × 10−10.
How common The T allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 6, band 6q25.3 — in a non-coding transcript of TULP4.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Lung function (forced vital capacity) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung function (forced vital capacity).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung function (forced vital capacity) compared to the general population.
Source
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Shrine N,
Izquierdo AG,
Chen J,
Packer R,
Hall RJ,
Guyatt AL,
Batini C,
Thompson RJ,
Pavuluri C,
Malik V,
Hobbs BD,
Moll M
and 136 more — show all
Kim W,
Tal-Singer R,
Bakke P,
Fawcett KA,
John C,
Coley K,
Piga NN,
Pozarickij A,
Lin K,
Millwood IY,
Chen Z,
Li L,
Wijnant SRA,
Lahousse L,
Brusselle G,
Uitterlinden AG,
Manichaikul A,
Oelsner EC,
Rich SS,
Barr RG,
Kerr SM,
Vitart V,
Brown MR,
Wielscher M,
Imboden M,
Jeong A,
Bartz TM,
Gharib SA,
Flexeder C,
Karrasch S,
Gieger C,
Peters A,
Stubbe B,
Hu X,
Ortega VE,
Meyers DA,
Bleecker ER,
Gabriel SB,
Gupta N,
Smith AV,
Luan J,
Zhao JH,
Hansen AF,
Langhammer A,
Willer C,
Bhatta L,
Porteous D,
Smith BH,
Campbell A,
Sofer T,
Lee J,
Daviglus ML,
Yu B,
Lim E,
Xu H,
O'Connor GT,
Thareja G,
Albagha OME,
Suhre K,
Granell R,
Faquih TO,
Hiemstra PS,
Slats AM,
Mullin BH,
Hui J,
James A,
Beilby J,
Patasova K,
Hysi P,
Koskela JT,
Wyss AB,
Jin J,
Sikdar S,
Lee M,
May-Wilson S,
Pirastu N,
Kentistou KA,
Joshi PK,
Timmers PRHJ,
Williams AT,
Free RC,
Wang X,
Morrison JL,
Gilliland FD,
Chen Z,
Wang CA,
Foong RE,
Harris SE,
Taylor A,
Redmond P,
Cook JP,
Mahajan A,
Lind L,
Palviainen T,
Lehtimäki T,
Raitakari OT,
Kaprio J,
Rantanen T,
Pietiläinen KH,
Cox SR,
Pennell CE,
Hall GL,
Gauderman WJ,
Brightling C,
Wilson JF,
Vasankari T,
Laitinen T,
Salomaa V,
Mook-Kanamori DO,
Timpson NJ,
Zeggini E,
Dupuis J,
Hayward C,
Brumpton B,
Langenberg C,
Weiss S,
Homuth G,
Schmidt CO,
Probst-Hensch N,
Jarvelin MR,
Morrison AC,
Polasek O,
Rudan I,
Lee JH,
Sayers I,
Rawlins EL,
Dudbridge F,
Silverman EK,
Strachan DP,
Walters RG,
Morris AP,
London SJ,
Cho MH,
Wain LV,
Hall IP,
Tobin MD
Nature genetics · 2023 · PMID 36914875 · open access
Questions about rs661857
What is rs661857?
rs661857 is a single position in the genome, in or near the TULP4 gene. Published research associates it with lung function (forced vital capacity). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs661857 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs661857 come from?
GWAS Catalog, Nature genetics 2023, PMID:36914875. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung function (forced vital capacity) (rs661857). MyGeneLog™. https://www.mygenelog.com/variants/rs661857
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