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Asthma

CAMK4 · rs6594500

Where this position leads

Condition: Asthma

rs6594500 Condition: Asthma Asthma Condition rs6594500 rs6594500 CAMK4

What the study found

Who was studied 46,802 European ancestry cases, 347,481 European ancestry controls; replicated in 23,948 European and unknown ancestry cases, 118,538 European and unknown ancestry controls.

The effect Each copy of the A allele carried 1.06 times the odds of Asthma (95% confidence interval 1.05-1.07); p = 4 × 10−20.

How common The A allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 5, band 5q22.1 — between genes, 4.8 kb from WDR36.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Asthma compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Asthma.
G/G Published research associates this genotype with typical/baseline likelihood of Asthma — no copies of the reported risk allele.
Source
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis
Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA Jr, Liang L
The European respiratory journal · 2019 · PMID 31619474

Questions about rs6594500

What is rs6594500?

rs6594500 is a single position in the genome, in or near the CAMK4 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6594500 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs6594500 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6594500 come from?

GWAS Catalog, The European respiratory journal 2019, PMID:31619474. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs6594500). MyGeneLog™. https://www.mygenelog.com/variants/rs6594500

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