Standard
Cerebrospinal fluid sTREM-2 levels
MS4A4A · rs6591561
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Cerebrospinal fluid sTREM-2 levels — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cerebrospinal fluid sTREM-2 levels.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cerebrospinal fluid sTREM-2 levels compared to the general population.
Source
The <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk
Deming Y,
Filipello F,
Cignarella F,
Cantoni C,
Hsu S,
Mikesell R,
Li Z,
Del-Aguila JL,
Dube U,
Farias FG,
Bradley J,
Budde J
and 24 more — show all
Ibanez L,
Fernandez MV,
Blennow K,
Zetterberg H,
Heslegrave A,
Johansson PM,
Svensson J,
Nellgård B,
Lleo A,
Alcolea D,
Clarimon J,
Rami L,
Molinuevo JL,
Suárez-Calvet M,
Morenas-Rodríguez E,
Kleinberger G,
Ewers M,
Harari O,
Haass C,
Brett TJ,
Benitez BA,
Karch CM,
Piccio L,
Cruchaga C
Science translational medicine · 2019 · PMID 31413141
Questions about rs6591561
What is rs6591561?
rs6591561 is a single position in the genome, in or near the MS4A4A gene. Published research associates it with cerebrospinal fluid strem-2 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6591561 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6591561 come from?
GWAS Catalog, Sci Transl Med 2019, PMID:31413141. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants