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neutrophil (fraction, minimum, inv-norm transformed)

near LINC01767 · rs6588629

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 65,556 African American or Afro-Caribbean individuals, 38,543 Hispanic or Latin American individuals, 3,443 East Asian ancestry individuals, 261,863 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0509 lower (95% confidence interval 0.04-0.061); p = 1 × 10−21.

How common The G allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 1, band 1p32.2 — between genes, 22.5 kb from LINC01767.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of neutrophil (fraction, minimum, inv-norm transformed) compared to the general population.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with neutrophil (fraction, minimum, inv-norm transformed).
T/T Published research associates this genotype with typical/baseline likelihood of neutrophil (fraction, minimum, inv-norm transformed) — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs6588629

What is rs6588629?

rs6588629 is a single position in the genome, in or near the near LINC01767 gene. Published research associates it with neutrophil (fraction, minimum, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6588629 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6588629 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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neutrophil (fraction, minimum, inv-norm transformed) (rs6588629). MyGeneLog™. https://www.mygenelog.com/variants/rs6588629

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