0 2023114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 592 Asian ancestry individuals, 8,819 Black individuals, 8,721 Hispanic or Latin American individuals, 20,333 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.095 lower (95% confidence interval 0.079-0.111); p = 1 × 10−31.
How common The A allele had a frequency of about 41% in the people studied.
Where it sits Chromosome 1, band 1p31.3 — in an intron of LEPR.
What ClinVar records
ClassificationBenign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-09-05.
ClinVar record 1267242NM_002303.6(LEPR):c.2673+3353T>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies of the version the research linked to C-reactive protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to C-reactive protein levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to C-reactive protein levels. This is the starting point the study compared everyone against.
rs6588153 is a single position in the genome, in or near the LEPR gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6588153 linked to?
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs6588153 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6588153 come from?
GWAS Catalog, Human molecular genetics 2024, PMID:38747556. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 2023114Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others14Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
C-reactive protein levels (rs6588153). MyGeneLog™. https://www.mygenelog.com/variants/rs6588153