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Cerebrospinal fluid protein FAS levels

FAS · rs6586166

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,524 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.443 lower (95% confidence interval 0.42-0.47); p = 7 × 10⁻²⁴¹.

How common The C allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 10, band 10q23.31 — in an intron of FAS.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cerebrospinal fluid protein FAS levels compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cerebrospinal fluid protein FAS levels.

T/T Published research associates this genotype with typical/baseline likelihood of Cerebrospinal fluid protein FAS levels — no copies of the reported risk allele.

Source

Low overlap of plasma and CSF protein quantitative trait loci affects protein discovery for neurological disease

Western D, Yang C, Timsina J, Liu M, Wang C, Campbell MC, Kotzbauer P, Perlmutter JS, Schindler SE, Morris JC, Holtzman DM, Alvarez I

and 12 more — show all

Pastor P, Wyss-Coray T, Marquié M, Cano A, Sung YJ, de Rojas I, Ruiz A, Budde J, Fernandez MV, Tarawneh R, Ibanez L, Cruchaga C

Science translational medicine · 2026 · PMID 42054495

Questions about rs6586166

What is rs6586166?

rs6586166 is a single position in the genome, in or near the FAS gene. Published research associates it with cerebrospinal fluid protein fas levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6586166 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6586166 come from?

GWAS Catalog, Science translational medicine 2026, PMID:42054495. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cerebrospinal fluid protein FAS levels (rs6586166). MyGeneLog™. https://www.mygenelog.com/variants/rs6586166

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