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Who was studied 217,530 European ancestry individuals (MTAG effective sample size boosted by osteoarthritis, rheumatoid arthritis and multiple sclerosis samples).
The effect
Each copy of the G allele shifted the measure 0.018 higher (95% confidence interval 0.012-0.024); p = 1 × 10−10.
How common The G allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 10, band 10q23.31 — in an intron of RNLS.
What each result means
A/ANo copy of the version the research linked to Endometriosis (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Endometriosis (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Endometriosis (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Human reproduction (Oxford, England) · 2025 · PMID 40262193 · open access
Questions about rs6586134
What is rs6586134?
rs6586134 is a single position in the genome, in or near the RNLS gene. Published research associates it with endometriosis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6586134 linked to?
On MyGeneLog this position is linked to Endometriosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs6586134 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6586134 come from?
GWAS Catalog, Human reproduction (Oxford, England) 2025, PMID:40262193. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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