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Its strongest genetic-study result is p = 10−7, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 22,350 European ancestry cases, 74,823 European ancestry controls, 11,025 East Asian ancestry cases, 162,608 East Asian ancestry controls, 999 African ancestry cases, 1,108 African ancestry controls, 986 South Asian ancestry cases, 1,258 South Asian ancestry controls, 511 Arab ancestry cases, 352 Arab ancestry controls.
The effect
Each copy of the T allele carried 0.95 times the odds of Rheumatoid arthritis (95% confidence interval 0.927840314176097-0.96531156568712); p = 5 × 10−8.
Where it sits Chromosome 7, band 7p12.2 — in an intron of IKZF1.
What each result means
A/ANo copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
A/TOne copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs6583441 is a single position in the genome, in or near the IKZF1 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6583441 linked to?
On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs6583441 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6583441 come from?
GWAS Catalog, Nature genetics 2022, PMID:36333501. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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