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TFRC protein levels

near FBXO45 · rs6583326

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0409 lower (95% confidence interval 0.03-0.052); p = 3 × 10−15.

How common The C allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 3, band 3q29 — between genes, 1.4 kb from FBXO45.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of TFRC protein levels compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with TFRC protein levels.
T/T Published research associates this genotype with typical/baseline likelihood of TFRC protein levels — no copies of the reported risk allele.
Source

Questions about rs6583326

What is rs6583326?

rs6583326 is a single position in the genome, in or near the near FBXO45 gene. Published research associates it with tfrc protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6583326 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6583326 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

TFRC protein levels (rs6583326). MyGeneLog™. https://www.mygenelog.com/variants/rs6583326

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