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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 9,232 European ancestry individuals; replicated in 2,318 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 63.3 mm3 lower (95% confidence interval 44.29-82.31); p = 7 × 10−11.
How common The C allele had a frequency of about 27% in the people studied.
Where it sits Chromosome 12, band 12q14.3 — between genes, 5.3 kb from APOOP3.
What each result means
A/ANo copy of the version the research linked to Hippocampal volume. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Hippocampal volume. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Hippocampal volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs6581612
What is rs6581612?
rs6581612 is a single position in the genome, in or near the WIF1 gene. Published research associates it with hippocampal volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs6581612?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs6581612 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6581612 come from?
GWAS Catalog, Nat Genet 2012, PMID:22504421. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 5132325223128Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity2Meta AI5Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others28Total51Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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