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Who was studied 60,620 European ancestry cases, 970,216 European ancestry controls.
The effect
Each copy of the G allele carried 1.07 times the odds of Atrial fibrillation (95% confidence interval 1.05-1.09); p = 2 × 10−17.
How common The G allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 5, band 5q31.3 — between genes, 3 kb from NR3C1.
What each result means
A/ANo copy of the version the research linked to Atrial fibrillation. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Atrial fibrillation. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Atrial fibrillation. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs6580277 is a single position in the genome, in or near the NR3C1 gene. Published research associates it with atrial fibrillation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6580277 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs6580277 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6580277 come from?
GWAS Catalog, Nat Genet 2018, PMID:30061737. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 326212422211Reads by AI crawlersClaude6ChatGPT2Google · Gemini1Perplexity2Meta AI4Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others11Total32Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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