Sensitive

Clear cell renal cell carcinoma

near DCAF4 · rs6574106

Where this position leads

What the study found

Who was studied 752,817 European ancestry individuals, 3,526 African American or Afro-Caribbean individuals, 3,457 Hispanic or Latin American individuals.

The effect Each copy of the C allele carried 1.12 times the odds of Clear cell renal cell carcinoma (95% confidence interval 1.09-1.16); p = 3 × 10⁻¹⁴.

How common The C allele had a frequency of about 26% in the people studied.

Where it sits Chromosome 14, band 14q24.2 — between genes, 7.4 kb from DCAF4.

What each result means

C/C Two copies of the version the research linked to Clear cell renal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Clear cell renal cell carcinoma. That is a smaller link than two copies.

T/T No copy of the version the research linked to Clear cell renal cell carcinoma. This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Purdue MP, Dutta D, Machiela MJ, Gorman BR, Winter T, Okuhara D, Cleland S, Ferreiro-Iglesias A, Scheet P, Liu A, Wu C, Antwi SO

and 120 more — show all

Larkin J, Zequi SC, Sun M, Hikino K, Hajiran A, Lawson KA, Cárcano F, Blanchet O, Shuch B, Nepple KG, Margue G, Sundi D, Diver WR, Folgueira MAAK, van Bokhoven A, Neffa F, Brown KM, Hofmann JN, Rhee J, Yeager M, Cole NR, Hicks BD, Manning MR, Hutchinson AA, Rothman N, Huang WY, Linehan WM, Lori A, Ferragu M, Zidane-Marinnes M, Serrano SV, Magnabosco WJ, Vilas A, Decia R, Carusso F, Graham LS, Anderson K, Bilen MA, Arciero C, Pellegrin I, Ricard S, Scelo G, Banks RE, Vasudev NS, Soomro N, Stewart GD, Adeyoju A, Bromage S, Hrouda D, Gibbons N, Patel P, Sullivan M, Protheroe A, Nugent FI, Fournier MJ, Zhang X, Martin LJ, Komisarenko M, Eisen T, Cunningham SA, Connolly DC, Uzzo RG, Zaridze D, Mukeria A, Holcatova I, Hornakova A, Foretova L, Janout V, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Gaborieau V, Abedi-Ardekani B, McKay J, Johansson M, Phouthavongsy L, Hayman L, Li J, Lungu I, Bezerra SM, Souza AG, Sares CTG, Reis RB, Gallucci FP, Cordeiro MD, Pomerantz M, Lee GM, Freedman ML, Jeong A, Greenberg SE, Sanchez A, Thompson RH, Sharma V, Thiel DD, Ball CT, Abreu D, Lam ET, Nahas WC, Master VA, Patel AV, Bernhard JC, Freedman ND, Bigot P, Reis RM, Colli LM, Finelli A, Manley BJ, Terao C, Choueiri TK, Carraro DM, Houlston R, Eckel-Passow JE, Abbosh PH, Ganna A, Brennan P, Gu J, Chanock SJ

BioBank Japan Project · FinnGen

Nature genetics · 2024 · PMID 38671320

Questions about rs6574106

What is rs6574106?

rs6574106 is a single position in the genome, in or near the near DCAF4 gene. Published research associates it with clear cell renal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6574106 linked to?

On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs6574106 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6574106 come from?

GWAS Catalog, Nature genetics 2024, PMID:38671320. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Clear cell renal cell carcinoma (rs6574106). MyGeneLog™. https://www.mygenelog.com/variants/rs6574106

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