Standard

Urate levels

near RPS6KA4 · rs656785

Where this position leads

Condition: Gout

rs656785 Condition: Gout Gout Condition rs656785 rs656785 near RPS6KA4

What the study found

Who was studied 342,087 European ancestry individuals, 6,011 African ancestry individuals, 7,328 South Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0229 higher (95% confidence interval 0.015-0.031); p = 3 × 10−9.

Where it sits Chromosome 11, band 11q13.1 — between genes, 2.9 kb from LINC02724.

What each result means

A/A Two copies of the version the research linked to Urate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Urate levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Urate levels. This is the starting point the study compared everyone against.
Source

Questions about rs656785

What is rs656785?

rs656785 is a single position in the genome, in or near the near RPS6KA4 gene. Published research associates it with urate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs656785 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs656785 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs656785 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urate levels (rs656785). MyGeneLog™. https://www.mygenelog.com/variants/rs656785

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