Who was studied 14,135 European ancestry cases, 58,126 European ancestry controls; replicated in 7,333 European ancestry cases, 42,468 European ancestry controls.
The effect
Each copy of the G allele carried 1.09 times the odds of Breast cancer (estrogen-receptor negative) (95% confidence interval 1.05-1.11); p = 9 × 10−10.
How common The G allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 13, band 13q22.1 — between genes, 24.2 kb from MARK2P12.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Breast cancer (estrogen-receptor negative) — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Breast cancer (estrogen-receptor negative).
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Breast cancer (estrogen-receptor negative) compared to the general population.
rs6562760 is a single position in the genome, in or near the KLF5 gene. Published research associates it with breast cancer (estrogen-receptor negative). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6562760 linked to?
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs6562760 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6562760 come from?
GWAS Catalog, Nat Genet 2017, PMID:29058716. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.