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Benign prostatic hyperplasia and lower urinary tract symptoms

RNASEH2B · rs6561599

Where this position leads

Condition: Benign Prostatic Hyperplasia

rs6561599 Condition: Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia Condition rs6561599 rs6561599 RNASEH2B

What the study found

Who was studied 20,621 European ancestry cases, 280,541 European ancestry controls.

The effect Each copy of the G allele carried 1.08 times the odds of Benign prostatic hyperplasia and lower urinary tract symptoms (95% confidence interval 1.04-1.1); p = 1 × 10−8.

How common The G allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 13, band 13q14.3 — in a non-coding transcript of RNASEH2B-AS1.

What each result means

C/C No copy of the version the research linked to Benign prostatic hyperplasia and lower urinary tract symptoms. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Benign prostatic hyperplasia and lower urinary tract symptoms. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Benign prostatic hyperplasia and lower urinary tract symptoms. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs6561599

What is rs6561599?

rs6561599 is a single position in the genome, in or near the RNASEH2B gene. Published research associates it with benign prostatic hyperplasia and lower urinary tract symptoms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6561599 linked to?

On MyGeneLog this position is linked to Benign Prostatic Hyperplasia. The research behind each link, and its sources, are set out on that condition page.

Does having rs6561599 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6561599 come from?

GWAS Catalog, Nature communications 2018, PMID:30410027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Benign prostatic hyperplasia and lower urinary tract symptoms (rs6561599). MyGeneLog™. https://www.mygenelog.com/variants/rs6561599

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