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Who was studied 4,442 European ancestry cases, 1,104,335 European ancestry controls; replicated in 725 cases, 164,346 controls.
The effect
Each copy of the A allele carried 1.25 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.16-1.34); p = 1 × 10−8.
How common The A allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 13, band 13q14.3 — in a regulatory region of DLEU7.
What each result means
A/ATwo copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.
Blood cancer journal · 2025 · PMID 40883272 · open access
Questions about rs6561593
What is rs6561593?
rs6561593 is a single position in the genome, in or near the DLEU7 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6561593 linked to?
On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs6561593 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6561593 come from?
GWAS Catalog, Blood cancer journal 2025, PMID:40883272. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1412227Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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